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See also Warning section.

This medication is used to deal with certain mental/mood disorders (schizophrenia, schizoaffective disorders). Clozapine is a medication that is psychiatricanti-psychotic type) that actually works by assisting to restore the balance of specific natural substances (neurotransmitters) within the brain.

Clozapine decreases hallucinations and aids in preventing committing suicide in people who are most likely to try to harm themselves. It can help you to definitely clearly think more and positively about yourself, feel less nervous, and indulge in everyday life.

How to use Clozaril

If you are utilizing the liquid form with this medication, read the Patient Information Leaflet if available from your pharmacist before you start taking clozapine and every time you get a refill. When you yourself have any relevant concerns, ask your doctor or pharmacist.

Take this medicine by mouth with or without food, as directed by your doctor. If you're taking the pills that dissolve in the mouth, carefully remove each tablet from the blister pack immediately before taking your dose. Allow the tablets to dissolve on your swallow and tongue. You do not need to take the dissolving tablets with water. Discard any dissolving tablets that have now been formerly subjected to air due to packaging that is opened/damaged. Do not save yourself them for your following dose.

If you use the liquid form of this medication, shake the bottle well for 10 seconds before each use. Carefully measure the dose using a special measuring device/spoon. Don't use a household spoon because may very well not obtain the dose that is correct.

It is critical to begin taking this drug at a dose that is low increasing your dose slowly, to lessen adverse effects such as dizziness, drowsiness and seizures. Follow your doctor's instructions exactly. Your dosage is based on your medical condition and response to treatment. Since clozapine can cause a decrease in white blood cells, you will need to get blood tests done regularly as directed. Be sure to keep all appointments of these laboratory tests. (See also Notes section.)

If you miss your doses for longer than a day or two, consult your doctor for a new schedule to get back to the dose you were on (see Missed Dose section). Use this medication regularly in order to get the most benefit from it. To greatly help you keep in mind, make use of it at the same time(s) each day.

Do not stop clozapine that is taking consulting your doctor. Some conditions may become worse when the drug is suddenly stopped. Also, you might experience symptoms such as severe sweating, headache, sickness, vomiting, and diarrhea. To prevent these signs while you are stopping treatment with this medication, your medical professional may reduce your dose slowly. Consult your pharmacist or doctor for more details. Report any new or symptoms that are worsening away.

It might take several weeks ahead of the full benefit of this medication takes effect. Inform your physician if your condition persists or worsens.

Part Effects

See section that is also warning.

Drooling, drowsiness, dizziness, headache, shaking tremor that is(, vision problems (e.g., blurred vision), weight gain, and constipation may occur. Many of these effects (especially drowsiness) lessen as your body gets used to the medication. If any of these effects persist or worsen, contact your pharmacist or doctor promptly.

To avoid constipation, keep a diet adequate in fiber, drink plenty of water, and exercise. If you feel constipated while using this drug, check with your pharmacist for help in selecting a laxative (e.g., stimulant-type with stool softener).

Understand that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of adverse effects. Many people using this medication do not have serious side effects.

This medicine may rarely make your blood sugar level rise, which can cause or worsen diabetes. Rarely, very conditions that are serious as diabetic coma may occur. Tell your medical practitioner immediately if you develop symptoms of high blood glucose, such as increased thirst and urination. If you already have diabetes, make sure to always check your blood sugars regularly. Your doctor might need certainly to adjust your diabetes medication, exercise program, or diet.

This medication may also cause significant weight gain and a rise in your cholesterol (or triglyceride) levels. These effects, along side diabetes, may increase your risk for developing heart condition. Talk about the dangers and benefits of therapy with your physician.

Tell your doctor right away for those who have any adverse that is serious, including: facial/muscle twitching, seizures, uncontrollable movements.

Get medical help right away if you have any really serious side impacts, including: severe dizziness, fainting, mental/mood changes, trouble respiration with exercise, sudden weakness, pain/redness/swelling of the arms/legs, persistent nausea/vomiting, stomach/abdominal pain, yellowing of eyes/skin.

This medication may hardly ever cause an extremely condition that is serious neuroleptic malignant syndrome (NMS). Get help that is medical away if you have any associated with following symptoms: temperature, muscle mass stiffness/pain/tenderness/weakness, serious tiredness, serious confusion, sweating, fast/irregular heartbeat, dark urine, improvement in the quantity of urine.

A very severe reaction that is allergic this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious reaction that is allergic include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the United States -

Call your doctor for medical advice about part results. You may report adverse effects to Food And Drug Administration at 1-800-FDA-1088 or at

In Canada - Call your doctor for medical advice about adverse effects. You'll report effects that are side Health Canada at 1-866-234-2345.


See also Warning and adverse Effects parts.

Before using clozapine, tell your physician or pharmacist in the event that you have any other allergies if you are allergic to it or. This product may contain inactive ingredients, which could cause allergies or other dilemmas. Confer with your pharmacist for additional information.

Before using this medicine, tell your physician or pharmacist your medical history, especially of: history of blood disorders (such as for instance leukemia, low white blood cell count), bowel problems (such as paralytic ileus, irritable bowel problem ), difficulty in breathing, diabetes/family history of diabetes, high cholesterol/triglyceride levels, glaucoma, heart problems, kidney problems, liver problems, obesity/family history of obesity, seizures, trouble urinating (such as prostate problems).

Clozapine may cause a disorder that impacts the center rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as serious dizziness, fainting) that require medical attention right away.

The possibility of QT prolongation may be increased if you have certain conditions that are medical are taking other drugs that could affect one's heart rhythm. Before utilizing clozapine, tell your physician or pharmacist of all of the the drugs you take and if you have any of the following conditions: certain heart dilemmas (heart failure, sluggish heartbeat, QT prolongation in the EKG), family history of certain heart related illnesses (QT prolongation in the EKG, unexpected cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you have conditions such as severe sweating, diarrhea, or vomiting if you use certain drugs (such as diuretics/"water pills") or. Confer with your doctor about making use of clozapine safely.

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision you can perform such activities safely until you are sure. Limit beverages that are alcoholic.

Tell your physician if you are a descendent of Ashkenazi Jews because you may be at a higher risk for a drop in your white blood cells.

Before having surgery, tell your dentist or doctor that you are using this medication.

Liquid services and products or dissolving tablets may contain sugar and/or aspartame. Liquid products may also contain alcohol. Caution is advised you to limit/avoid these substances in your diet if you have diabetes, liver disease, phenylketonuria (PKU), or any other condition that requires. Ask your pharmacist or doctor about applying this product safely.

Older adults may be more sensitive to the relative side ramifications of this medication, particularly constipation, dizziness, and QT prolongation (see above). Dizziness can raise the risk of falling.

During pregnancy, this medicine should be used only when demonstrably needed. Babies born to mothers who purchased this medication over the last 3 months of pregnancy may rarely develop symptoms including muscle stiffness or shakiness, drowsiness, feeding/breathing difficulties, or constant crying. If you notice any of these symptoms in your newborn especially during their first month, tell the doctor right away.

Since untreated mental/mood dilemmas (such as schizophrenia, schizoaffective disorders) can be a condition that is serious do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.

This medicine may pass into breast milk while having effects that are undesirable a nursing infant. Breast feeding is not advised while taking clozapine. Consult your physician before breast-feeding.

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