Methotrexate is used to treat certain forms of cancer tumors or to control psoriasis that is severe rheumatoid arthritis that has not responded to other treatments. It may also be used to control rheumatoid arthritis that is juvenile. Methotrexate belongs to a class of drugs called antimetabolites. It works by slowing or stopping the growth of cancer cells and suppressing the immune system.
Early remedy for rheumatoid arthritis with more aggressive therapy such as for example methotrexate helps to reduce further joint harm and to preserve joint function.
OTHER USES: This section contains uses of this medication being not placed in the approved professional labeling for the drug but which will be prescribed by your health care expert. Make use of this medication for a state of being which is placed in this area only if this has been so prescribed by your medical care professional.
This medicine doubles for lupus and psoriatic arthritis.
Read the Patient Information Leaflet if available from your pharmacist before you start taking methotrexate and each time you get a refill. If you have any relevant questions, ask your doctor or pharmacist.
Methotrexate is a medication that is strong. The dosage and how often you take this medication are based on your condition that is medical and to therapy. There are many dosing that is different for this medication (especially for cancer therapy). Therefore, it is vital that you follow your physician's directions carefully. Take this medicine by lips as directed by the doctor.
For the treatment of psoriasis or arthritis rheumatoid, simply take this medicine by mouth as directed by your physician, often as soon as a week. It might take around a few months before you get the benefit that is full of medication.
Never increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of unwanted effects will increase.
Since this drug can be absorbed through skin and lung area and might harm an unborn baby, ladies who are pregnant or who may become pregnant must not manage this medication or breathe the dust through the pills.
Drink plenty of liquids while taking this medication unless your medical professional tells you otherwise. Doing so assists your kidneys to eliminate the medication from the body and prevent a number of the relative side-effects.
See section that is also warning.
Sickness, vomiting, stomach pain, drowsiness, or dizziness might occur. If any of these effects persist or worsen, tell your pharmacist or doctor quickly.
Temporary hair loss might occur. Normal hair growth should return after therapy has ended.
Remember that the doctor has prescribed this medication she has judged that the benefit to you is greater than the risk of side effects because he or. Many people using this medication do not have adverse that is serious.
Inform your doctor right away if you have any serious adverse effects, including: mouth sores, diarrhea, signs of anemia (such as unusual tiredness, pale skin), signs of liver problems (such as for instance dark urine, persistent nausea/vomiting, stomach/abdominal pain, yellowing eyes/skin), easy bruising/bleeding, black stools, enlarged glands/lymph nodes, bone pain, unusual discomfort and discoloration of skin, change in the quantity of urine, dry cough, muscle weakness.
Get medical help right away if you have got any really serious side-effects, including: weakness on one part for the body, throat stiffness, serious frustration, eyesight changes, irregular heartbeat, mental/mood changes, seizures.
This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as fever, chills, persistent sore throat, cough).
This medication can affect sperm production, a result that may reduce fertility that is male. Check with your doctor for more details.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any observeable symptoms of a serious allergic reaction, including: rash, itching/swelling (especially for the face/tongue/throat), severe dizziness, trouble breathing.
This is simply not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your medical professional for medical advice about unwanted effects. You could report effects that are side FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about unwanted effects. You may report effects that are side Health Canada at 1-866-234-2345.
See also Warning section.
Before taking methotrexate, tell your physician or pharmacist if you have any other allergies if you are allergic to it; or. This product may contain inactive ingredients, which could cause sensitive responses or other dilemmas. Talk to your pharmacist for more details.
Before making use of this medication, tell your doctor or pharmacist your medical history, particularly of: liver condition, renal disease, lung disease (such as pulmonary fibrosis), alcohol usage, suppressed immune system, blood cell/bone marrow disorders, stomach/intestinal diseases (such as peptic ulcer, ulcerative colitis), any active infection (including chickenpox or recent exposure to it), folic acid deficiency.
Methotrexate can make you more likely to get infections or may worsen any current infections. Therefore, clean both hands well to stop the spread of infection. Avoid contact with those who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been confronted with an infection or for more details.
Don't have immunizations/vaccinations without the consent of your physician. Avoid experience of people who have recently received live vaccines (such as for instance flu vaccine inhaled through the nose).
To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and prevent activities such as contact sports.
This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.
Before having surgery, tell your doctor or dentist about all these products you use (including prescription drugs, nonprescription medications, and herbal products).
This medicine might make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.
Methotrexate must not be utilized during pregnancy. It could harm an baby that is unborn. It is important to prevent pregnancy during and after treatment with methotrexate. Therefore, males and females must use reliable forms of birth control (such as condoms, birth control pills) during treatment. Males should continue to use birth control for at least 3 months after the final end of treatment. Females should continue to use birth control for at minimum 1 menstrual cycle after the end of treatment. If you become pregnant or think you may be pregnant, tell your doctor right away.
Because this drug can be consumed through the epidermis and lungs and may harm an baby that is unborn women who are pregnant or who may become pregnant should not manage this medicine or inhale the dust through the tablets.
Methotrexate passes into breast milk and may harm a medical infant. Therefore, breast-feeding when using this drug is not recommended. Consult your doctor before breast-feeding.
Airmail: 2-3 business weeks, EMS: 3-8 business days.
Airmail: 2-3 business weeks, EMS: 3-8 business days.