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Uses

Generic Motilium is used to supress sickness and vomiting, and works primarily by blocking dopamine receptors found in the upper end of the system that is digestive. This causes tightening of the muscles at the entry to the stomach, relaxation of the muscles at the exit of the stomach and increased contraction of the muscles in the stomach itself. These actions speed up the passage of food through the stomach into the intestine, which physically helps prevent vomiting and reduces feelings of sickness, bloating and fullness. It also prevents food from flowing the wrong way through the stomach and thus prevents reflux (regurgitation of the stomach articles back into the foodpipe).

adverse Effects

Unwanted effects consist of:

 

Precautions

Since domperidone is highly metabolised in the liver, domperidone should be used with caution in patients with hepatic disability (and in the elderly).

Domperidone must be used with caution in clients with renal disability or in those at risk of fluid retention. In patients with severe insufficiency that is renalserum creatinine more than 6mg/100ml, i.e. more than 0,6mmol/L) the elimination half-life of domperidone was increased from 7,4 to 20,8 hours. The dosing frequency should once be reduced to or twice daily, with regards to the severity of impairment, and the dose may require to be paid off. Patients on prolonged therapy should regularly be reviewed.


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