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This combination medication is used to take care of signs of Parkinson's disease or symptoms that are parkinson-likesuch as shakiness, stiffness, difficulty moving). Parkinson's disease is thought to be caused by too little of a naturally occurring substance (dopamine) into the brain. Levodopa changes into dopamine in mental performance, assisting to control movement. Carbidopa stops the breakdown of levodopa in the bloodstream therefore more levodopa can enter the brain. Carbidopa can also reduce some of levodopa's part effects such as nausea and vomiting.

Exactly how to use Sinemet

Take this medication by lips with or without meals as directed by the doctor, often 3 to 4 times a day.

Using this medication with food might help to decrease nausea. It is best to avoid a high-protein diet (it decreases the quantity of levodopa that your particular body takes in) during therapy, unless directed otherwise by your doctor. Separate your dose with this medication by as many hours as possible from any iron supplements or products containing iron (such as multivitamins with minerals) you may take. Iron can reduce the amount of this medication absorbed by the body. Consult your doctor or pharmacist to get more details.

The dosage is situated on your medical condition and response to treatment. To reduce your risk of adverse effects, your doctor may direct you to start this medication at a dose that is low gradually increase your dose. Follow your doctor's directions very carefully. This combination medication comes in different strengths with various amounts of carbidopa and levodopa in each tablet. Be sure you have the strength that is correct of drugs. Your doctor may also prescribe carbidopa alone to be taken with this combination.

Utilize this medication regularly to get the benefit that is most from it. Each day to help you remember, take it at the same times.

Some clients may experience a "wearing-off" (worsening of symptoms) before the dose that is next due. An "on-off" impact may additionally take place, in which unexpected short periods of stiffness occur. If these effects occur, contact your doctor for feasible dosage adjustments that may help to reduce this effect.

Do not stop taking this medication without consulting your physician. Some conditions may become worse when this medication is quickly reduced or suddenly stopped. Your dose may need to be gradually reduced. (See also negative effects section.)

Inform your doctor when your condition does not enhance or if it worsens.

Side Impacts

Dizziness, lightheadedness, sickness, vomiting, loss of appetite, trouble sleeping, uncommon dreams, or headache may happen. If some of these effects persist or worsen, tell your pharmacist or doctor quickly.

This medication may cause saliva, urine, or sweat to turn a color that is dark. This impact is harmless, your clothes can be stained.

To cut back the risk of dizziness and lightheadedness, get up slowly when increasing from a sitting or lying position.

Remember that your doctor has prescribed this medicine she has judged that the benefit to you is greater than the risk of adverse effects because he or. Many people using this medication do not have side that is serious.

Some people taking this medication have fallen asleep abruptly in their usual activities that are dailysuch as talking on the phone, driving). In some full situations, sleep occurred without any feelings of drowsiness in advance. This sleep effect may occur anytime during therapy with carbidopa/levodopa even though you purchased this medication for a time that is long. If you experience increased sleepiness or fall asleep during the day, do not drive or do other possibly dangerous activities until you have discussed this effect with your doctor. Your risk with this sleep effect is increased by making use of liquor or other medicines that will allow you to drowsy. See also Precautions section.

Tell your doctor straight away if you have any serious side effects, including: new/worsening movements you can't control/spasms, greatly increased eye blinking/twitching, fainting, vision changes (such as blurred vision, double vision), eye pain, severe stomach/abdominal pain, black/tarry stools, vomit that looks like coffee grounds, mental/mood changes (such as agitation, hallucinations, depression, thoughts of suicide), signs of infection (such as sore throat that doesn't go away), easy bleeding/bruising, unusual tiredness, tingling of the hands/feet, unusual strong urges (such as increased gambling, increased sexual urges).

Get help that is medical away if you have any very serious side effects, including: chest pain.

Abruptly stopping or reducing the dose of the medicine may seldom cause a really condition that is serious neuroleptic malignant syndrome (NMS). Get medical help right away for those who have any of the after symptoms: temperature, uncommon muscle mass stiffness, serious confusion, perspiring, fast/irregular heartbeat, fast breathing.

a very serious allergic reaction to this drug is rare. However, get help that is medical away in the event that you notice any observeable symptoms of a critical allergic reaction, including: rash, itching/swelling (especially associated with the face/tongue/throat), serious dizziness, difficulty respiration.

This is maybe not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about adverse effects. You might report side effects to FDA at 1-800-FDA-1088 or at

In Canada - Call your physician for medical advice about part impacts. You may report effects that are side Health Canada at 1-866-234-2345.


Before using this medication, tell your doctor or pharmacist if you have any other allergies if you are allergic to carbidopa or levodopa; or. This product may contain inactive ingredients, which can cause allergies or other problems. Speak to your pharmacist for lots more details.

Before using this medicine, tell your doctor or pharmacist your health background, especially of: liver disease, glaucoma, respiration issues (such as for instance asthma), heart disease (such as coronary attack, irregular heartbeat), kidney infection, stomach/intestinal ulcer, mental/mood disorders (such as depression, schizophrenia), blood disorders, seizures, sleep disorders.

This drug might make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness you can perform such activities safely until you are sure. Limit beverages that are alcoholic. See also Side Effects section.

Before having surgery, tell your doctor or dentist about all of the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only once plainly needed. Discuss the risks and benefits with your physician.

Levodopa passes into breast milk. It is unknown if carbidopa passes into breast milk. Consult with your doctor before breast-feeding.

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